Ulcerative colitis


The cause of the disease is unknown but there are several theories about hereditary, infectious and immunological factors. Ulcerative colitis is a non-bacterial inflammation in the mucosa of the large intestine causing sores and bleeding ulcers. The disease fluctuates with periods of blood and pus stained diarrhoea and abdominal pain.

Typical symptoms are frequent watery diarrhoeas and stool containing blood and/or pus. The diarrhoea is often preceded by strong left-sided abdominal pain that is relieved by bowel emptying. Nausea, fever and weight loss are also common. The symptoms do tend to come and go, with fairly long periods in between flare-ups in which patients may experience no distress at all. The frequency can range from one flare during the entire course of life to daily problems. In more severe cases of ulcerative colitis it may be necessary to surgically remove part of or the entire intestine and replace them with a stoma (an opening on the abdomen through which waste are emptied into a pouch).

Clinical studies

AF treatment in ulcerative colitis

A randomised double-blind study was performed to see if AF inducing cereals could promote endogenous AF production in patients with ulcerative colitis and Crohn's disease, and to determine if an elevated AF level was correlated to clinical improvement of intestinal function.

The experimental group consisted of 26 patients given AF inducing cereals as muesli, bread and/or pasta in addition to their regular diet during 30 days. A control group of 24 received a similar diet without the AF inducing properties. Patients were asked to keep a diary over bowel symptoms, and plasma levels of AF and rectal biopsies were evaluated before and after treatment.

Results showed that the patients receiving active treatment significantly improved intestinal function correlating to increased plasma AF levels (p<0,001). Elevated AF levels were sustained one month after treatment. No effect was seen in the placebo group (fig. 1). A significant accumulation of AF in intestinal epithelial cells of the active treatment group was seen with colonic biopsies.

Subjective ratings of clinical symptoms according to VAS were significantly improved (p<0,05) in the group receiving active treatment (mean +34,6%) compared with placebo (mean 15,4%) (fig. 2).

Figur1. Patients treated with specially processed cereals (SPC) has significantly higher AF-levels in plasma compared to placebo. SPC-treated patients also got a significant better intestinal function.

Figure 2. AF-treated patients showed a significant improvement in subjective symptons as compared to the placebo group.

Due to the findings of this study the surgeons have begun AF-treatment of more patients undergoing GI-surgery in which through experience the outcome is known to lead to reduced intestinal function.

The treatment is initiated by already on the first day administer Salovum® dissolved in ordinary juice. This will quickly lead to high AF levels in the intestine without first letting the body produce it by its own. Most often the patients initially treated with Salovum® for 5-10 days can then be transferred to the AF inducing SPC-Flakes® in order to stimulate the endogenous AF production.

Björck, Bosaeus, Ek, Jennische, Lönnroth, Johansson and Lange, Food induced stimulation of the antisecretory factor can improve symptoms in human inflammatory bowel disease: A study of a concept, Gut, 2000; 46:824-829, view link

SPC-Flakes® in IBD in children

The first pilot study in children with ulcerative colitis and Crohn's disease revealed that the clinical symptoms improved and that treatment with SPC-Flakes® is a safe and well tolerated treatment. The positive study results will be followed up with a randomised double-blind study.

Finkel, Bjarnason, Lindblad and Lange, Specially Processed Cereals: A clinical innovation for children suffering from inflammatory bowel disease?, Scand J of Gastroenterol, 2004; 39:87-88, view link


Expected treatment outcome

SPC-Flakes® is a maintenance treatment and the purpose is to stimulate the body’s own production of the AF protein. A positive therapeutic response can normally be seen after 10-15 days. The treatment should last at least one month to determine the effect of the treatment. After termination of the treatment AF levels will decline again after a few weeks. If treatment is resumed, AF levels will rise within a matter of days, indicating a biological memory for AF production. 

In the absence of a treatment effect with SPC-Flakes® this may be due to the dose being too low or that some patients’ bodies are unable to produce AF. Clinical studies demonstrate that these patients might be helped with Salovum® which is a way of supplying high doses of the AF protein without having the body produce it on its own.


Normal dosage of AF-inducing cereals, SPC-Flakes®, is 1 g/kg bodyweight daily, divided into 2-3 occasions. When treating children the dose may need to be increased and when treating elderly it may need to be reduced. The dosage should be introduced step by step and reach full dosage after 4-6 days. The cereals can be eaten with yoghurt or boiled to a porridge without loosing the effect. 1 dl of SPC-Flakes® equals approximately 50 g.


Side effects, interactions and precautions

AF products have been eaten by tens of thousands of individuals and no side effects of medical nature have been reported. A few patients have experienced occasional constipation, but this discomfort can be reduced by a step-by-step introduction of the treatment. 

There are no reported interactions with concomitant medications. This is of importance as the patients should continue with their regular medical treatment. SPC-Flakes® should not replace or change the patients’ current medication. Persons with coeliac disease or gluten intolerance should not be treated with SPC-Flakes®.

Where to buy, Prescriptions

SPC-Flakes® can be bought prescription free in pharmacies or in health food shops. As of December 31, 2010, Läkemedelsverket (The Medical Products Agency) has decided to include SPC-Flakes® and Salovum® in the new revised list for food for particular nutritional use for children under 16 years of age (“Särnär”, LVFS 2010:27 ) and the cost will thus be included within the national benefit scheme for prescription drugs.
For patients 16 years of age or older, dieticians and most doctors can prescribe SPC-Flakes® as “sär-när”, foods for particular nutritional uses certified by the National Food Administration (Livsmedelsverket). The cost of the products varies between the different counties (landsting).