Clinical Studies

A large number of studies of Protein-AF have been published. Find them on PubMed by clicking on this link and search for "antisecretory factor".

Clinical studies can also be found with a common internet search, using words such as "protein antisecretory factor", "Protein-AF", "SPC-Flakes" and ”Salovum".

Find a short-list of clinical studies below.

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Salovum - Clinical Studies

Diarrhea - Inflammatory bowel diseases:

  • Effect of Antisecretory Factor in Ulcerative Colitis on Histological and Laborative Outcome; a Short Period clinical trial, Scand J of Gastroenterol, Eriksson et al. (2003)

  • P517 Efficacy of antisecretory factor in reducing high intestinal output in patients with ileostomy for Crohn ́s disease, poster presentation at Clinical Therapy and Observation, Scribano et al. (2015)

  • IBD and diarrhea - Karolinska University, Lllejbo (case study) 

Diarrhea – General:

  • Antisecretory factor counteracts secretory diarrhea of endocrine origin, Clinical Nutrition, Laurenius et al. (2003)

Diarrhea - Children:

  • The antisecretory factor – an efficient tool for rapid recovery from early childhood diarrhoea, Acta Paediatrica, Zaman et al. (2013)

  • B 221, a medical food containing antisecretory factor reduces child diarrhoea: a placebo-controlled trial, Acta Paediatrica, Zaman et al. (2007) 

  • Antisecretory factor effectively and safely stops childhood diarrhoea: a placebo-controlled, randomised study, Acta Paediatrica, Zaman et al. (2014)

  • High doses of Antisecretory Factor stops diarrhea fast without recurrence for six weeks post treatment, Internal Journal of Infectious diseases, Zaman et al. (2018) 

Ménière:

  • Antisecretory Factor: A Clinical Innovation in Ménière’s Disease? Acta Oto-Laryngologica, Hanner et al. (2003)

SPC-Flakes - Clinical Studies

Diarrhea:

  • Specially Processed Cereals: A clinical innovation for children suffering from inflammatory bowel disease? Scand J of Gastroenterol, Finkel et al. (2004)

  • Food-induced antisecretory factor activity is correlated with small bowel length in patients with intestinal resection, APMIS, Lange et al. (2003)

  • Food induced stimulation of the antisecretory factor can improve symptoms in human inflammatory bowel disease: A study of a concept, Gut, Björck et al. (2000)

  • Födoinducerad ökning av antisekretorisk faktor förbättrade det kliniska tillståndet hos sex patienter med svår Crohns sjukdom, Posterpresentation vid Riksstämman, Shafazand et al. (2003)

  • Effects of anti-secretory factor (ASF) on irritable bowel syndrome (IBS), Scandinavian Journal of Primary Health Care, Ekesbo et al. (2008)

  • Antisecretory factor counteracts secretory diarrhea of endocrine origin, Clinical Nutrition, Laurenius et al. (2003)

  • IBD and diarrhea - Karolinska University, Lllejbo (case study)

Ménière:

  • Increased antisecretory factor reduces vertigo in patients with Ménière’s disease: a pilot study, Hearing Research, Hanner et al. (2004)

  • Antisecretory factor-inducing therapy improves the clinical outcome in patients with Ménière’s disease, Acta Oto-Laryngologica, Hanner et al. (2010)

  • Antisecretory Factor – Inducing Therapy Improves Patient-Reported Functional Levels in Meniere ́s Disease, Annals of Otology, Rhinology & laryngology, Leong et al. (2013)

  • Food induced stimulation of the antisecretory factor to improve symtoms in Ménière’s disease, Eur Arch Otorhinolaryngol, Scarpa et al. (2020).

  • SPC-Flakes in the prophylaxis of Ménière’s disease, Proceedings of the 7th International Symposium on Ménière ́s Disease and Inner Ear Disorders, Teggi et al. (2013)

  • Anti-inflammatorisk effekt av kosttillskott med specialprocessade cerealier vid reumatoid artrit – en dubbel-blind pilotstudie, Posterpresentation vid Riksstämman, Mörck et al. (2003)

  • The role of endogenous Antisecretory Factor in the treatment of Ménière's Disease A two-year follow-up study, Am J Otolaryngol, Viola et al (2020)